Definition定义 Disseminated intravascular coagulation(DIC)is a clinicopathologic syndrome in which widespread intravascular coagulation is induced by procoagulants that are introduced or produced in the blood and overcome the natural anticoagulant mechanisms.Perturbation of the endothelium in the microcirculation along with stimulated inflammatory cells play a key role in its mechanism.广泛血管内凝血的临 床病理综合症，内皮损害和炎症细胞刺激是关键。 The clinical manifestations of intravascular coagulation include(1)multiorgan dysfunction caused by microthrombi, (2)bleeding caused by consumption of platelets,fibrinogen, factor V,and factor VIll,and (3)secondary fibrinolysis and platelets exhaustion..微血管内血栓、 凝血因子血小板消耗、 继发性纤溶活化和出血表现。 Definition 定义 • Disseminated intravascular coagulation (DIC) is a clinicopathologic syndrome in which widespread intravascular coagulation is induced by procoagulants that are introduced or produced in the blood and overcome the natural anticoagulant mechanisms. Perturbation of the endothelium in the microcirculation along with stimulated inflammatory cells play a key role in its mechanism. 广泛血管内凝血的临 床病理综合症，内皮损害和炎症细胞刺激是关键。 • The clinical manifestations of intravascular coagulation include (1) multiorgan dysfunction caused by microthrombi, (2) bleeding caused by consumption of platelets, fibrinogen, factor V, and factor VIII, and (3) secondary fibrinolysis and platelets exhaustion. 微血管内血栓、凝血因子血小板消耗、 继发性纤溶活化和出血表现