A Ligand-gated Dephosphorylate Chan Regulation of gating in ion channels. Several types of gating are shown for ion channels A)Ligand-gated channels open in response to ligand D Stretch or pressure-gated bi Inding Stretch B)Protein phosphorylation or dephosphory lation regulate opening and closing of some ion channels C)Changes in membrane potential alter channel openings D)Mechanical stretch of the membrane results in channe Cytoskeleton opening bysiology:www.accessmedicine.conRegulation of gating in ion channels. Several types of gating are shown for ion channels. A) Ligand-gated channels open in response to ligand binding. B) Protein phosphorylation or dephosphorylation regulate opening and closing of some ion channels. C) Changes in membrane potential alter channel openings. D) Mechanical stretch of the membrane results in channel opening