Clinical manifestations Short stature: slow growth in height, Congenital form: birth length is below the mean, 2-4Sd below the mean by 1 vear of age Acquired form: normal initially, growth faillure gradually appear and progress Delayed closure of the epiphyses. The head is round the face is short and broad The neck is short, the voice is high-pitched, the genitals are undeveloped and sexual maturation may be delayed or absent. The scalp hair is fine. Some with acte、TSH、 gnrh and aDh deficiencyClinical manifestations • Short stature: slow growth in height, • Congenital form: birth length is below the mean, 2-4Sd below the mean by 1 year of age. • Acquired form: normal initially, growth faillure gradually appear and progress • Delayed closure of the epiphyses. • The head is round, the face is short and broad. The neck is short, the voice is high-pitched, the genitals are undeveloped and sexual maturation may be delayed or absent. The scalp hair is fine. • Some with ACTH、TSH、GnRH and ADH deficiency