Preface to the Secondedition The second edition of the Fermentation and Biochemical Engineer- ing Handbook, like the previous edition, is intended to assist the develo ment, design and production engineer who is engaged in the fermentation industry. Particularemphasis is give to those unit operations most frequentl encountered in the commercial production of chemicals and pharmaceuticals ia fermentation, separation, and purification Some theory is included to provide the necessary insight into the unit operation but is not emphasized. Rather, the emphasis is placed on the practical aspects of development, design and operation how one goes about collecting design data, what are the scale-up parameters, how to select the right piece of equipment, where operating problems arise and how to troubleshoot The text is written from a practical and operating viewpoint, and all of the contributing authors have been chosen because of their industrial background and orientation. Several of the chapters which were in the first edition have been either deleted or replaced by other chapters which are more germane to current fermentation practice Those chapters which were retained have been updated or have been rewritten to reflect current practice. Several new chapters were intro duced to reflect current emphasis on cell cultures, nutritional require- ments, statistical methods for fermentation optimization, cross-flow filtration, environmental concems, and plant designPreface to the Second Edition The second edition ofthe Fermentation andBiochemica1 Engineer￾ing Handbook, like the previous edition, is intended to assist the develop￾ment, design and production engineer who is engaged in the fermentation industry. Particular emphasis is give to those unit operations most frequently encountered in the commercial production ofchemicals and pharmaceuticals via fermentation, separation, and purification. Some theory is included to provide the necessary insight into the unit operation but is not emphasized. Rather, the emphasis is placed on the practical aspects of development, design and operation-how one goes about collecting design data, what are the scale-up parameters, how to select the right piece of equipment, where operating problems arise, and how to troubleshoot. The text is written from a practical and operating viewpoint, and all of the contributing authors have been chosen because of their industrial background and orientation. Several of the chapters which were in the first edition have been either deleted or replaced by other chapters which are more germane to current fermentation practice. Those chapters which were retained have been updated or have been rewritten to reflect current practice. Several new chapters were intro￾duced to reflect current emphasis on cell cultures, nutritional require￾ments, statistical methods for fermentation optimization, cross-flow filtration, environmental concerns, and plant design vi