Impairment of atP7B Impairment of aTP7B causes copper to accumulate in the liver-(it does not bind to cerluoplasmin) High levels of copper in the liver causes oxidative damage through a process known as Fentons Chemistry Oxidative damage in the liver leads to chronic Active HepatitisImpairment of ATP7B • Impairment of ATP7B causes copper to accumulate in the liver – (it does not bind to cerluoplasmin) • High levels of copper in the liver causes oxidative damage through a process known as Fenton’s Chemistry • Oxidative damage in the liver leads to Chronic Active Hepatitis