Complement Complement.Serum proteins,found in the blood,along with cells of the immune system work together to eliminate foreign cells.Once activated,the complement system can bring about a variety of responses.This complement system consists of three separate Along with this triggers,there are also two sets of mechanisms.Both of these mechanisms, classical pathway and alternative or properdin pathway,make MAC (Membrane Attack Complex),which can lyse and destroy the cell. Complement(Heat-Labile Substance) Destroy No Heat, by Heat but nent 000 Cell Lysis No Cell Lysis Complement,antibodies,and cellular antigens are required for cell lysis C1, C4,C2,C3 C5,C6,C7,C8,C9 Discharge of ysosom al enzyme C3a Histamine release _Inflammation C4a edema Complement Complement. Serum proteins, found in the blood, along with cells of the immune system work together to eliminate foreign cells. Once activated, the complement system can bring about a variety of responses. This complement system consists of three separate activation triggers: (1) Ab binding to a cell surface, (2) formation of immune complexes, and (3) a carbohydrate component of a microbe's cell membrane. Along with this triggers, there are also two sets of mechanisms. Both of these mechanisms, classical pathway and alternative or properdin pathway, make MAC (Membrane Attack Complex), which can lyse and destroy the cell