Experimental proof that most of the transcribed dna is bound to nucleosomes erythrocyte or oviduct cell Extract chromatin NAsc 1- sitive regions Digest with DNase I Percent maxlmum until 10 of DNA is binding of radioactive c NA Radioactive to DNA extracted DNase CDNA from treated Isolate DNA from chromatin chromatin Red blood cell DNA Globin cdNa Craln cell chromatin Globin CDNA 9400 Fibroblast chromatin+ Globin cDNA 9100 hybridize with probe Probe Red bood cell chromalin Globin cDnA hybridized Red Wood ell chromatin+ Ovalbumin cDNA 90-100 Stme After Weintraub and gnudine, 19?Experimental proof that most of the transcribed DNA is bound to nucleosomes