Epstein-Barr Virus .EBV infection is usually spread by saliva Lymphoproliferative Disease ° Burkitt Lymphoma : 90% in and only -20% in the US are associated with the virus .African patients with Burkitt lymphoma often have high levels of antibody to EBV antigens Burkitt lymphomas contain chromosomal translocations that result in c-myc dysregulation . Procedure First, EBv infection may expand the pool of differentiating and proliferating B cells . Second, chronic endemic malaria may cause T-cell suppression and B-cell proliferation . Third, cmyc(t[8; 14]ort[8, 22])translocation .Nasopharyngeal Carcinoma .the level of EBV dNa in plasma .Nasopharyngeal carcinoma tissue contains EBv genomes in every cellEpstein-Barr Virus •EBV infection is usually spread by saliva. •Lymphoproliferative Disease •Burkitt Lymphoma •90% in and only ~20% in the US are associated with the virus. •African patients with Burkitt lymphoma often have high levels of antibody to EBV antigens. •Burkitt lymphomas contain chromosomal translocations that result in c-myc dysregulation. •Procedure: •First, EBV infection may expand the pool of differentiating and proliferating B cells. •Second, chronic endemic malaria may cause T-cell suppression and B-cell proliferation. •Third, cmyc (t[8;14] or t[8;22]) translocation •Nasopharyngeal Carcinoma •the level of EBV DNA in plasma •Nasopharyngeal carcinoma tissue contains EBV genomes in every cell