Nucleic Acid Hybridization:DNA chip (a)A DNA chip can be manufactured to contain (c)The unknown DNA is inserted into the chip and hundreds of thousands of synthetic single- allowed to hybridize with the DNA on the chip. stranded DNA sequences.Assume that each DNA sequence was unique to a different bacterial species. →<《 (b)Unknown DNA from a patient is separated into (d) The tagged DNA will bind only to the complementary single strands,enzymatically cut,and labeled DNA on the chip.The bound DNA will be detected by with a fluorescent dye. its fluorescent dye and analyzed by a computer.The red light is a gene expressed in normal cells;green is a mutated gene expressed in tumor cells;and yellow,in both cells. Figure 10.17 Nucleic Acid Hybridization: DNA chip Figure 10.17