Carcinogens and Tobacco-Induced cancers Cancer Likely Carcinogen Type Involvement PAH, NNK(major) 1, 3-butadiene, isoprene, ethylene oxide, ethyl carbamate, ald hydes, benzene, metals Larynx PAH Nasal NNK, NNN, other N-nitrosamines aldehydes Oral cavity PAH, NNK, NNN Esophagus NNN, other N-nitrosamines Lⅳer NNK, other N-nitrosamines, furan Pancreas NNK NNAL Bladder 4-Aminobiphenyl, other aromatic m Leukemia Benzene Holland-Frei cancer Medicine. 2010Carcinogens and Tobacco-Induced Cancers Holland-Frei Cancer Medicine, 2010