1/26/2016 Disease due to microbes is a rare event. Microbes Microbes do not try to cause disease. Microbes are looking for food and defending themselves. Invisible Invaders Amazing Allies Chapter 15 Microbial Mechanisms of Pathogenicity Common How Microorganisms Enter a Host strategies of pathogenicity Learning Objectives A thorough understanding is Identify the principal portals of entry. esesntial to develop Define IDso and LDso better,novel vaccines and Using examples,explain how microbes therapeutic agents adhere to host cells. for treatment and prevention 1/26/2016 1 Invisible Invaders Amazing Allies Chapter 15 Microbial Mechanisms of Pathogenicity • Disease due to microbes is a rare event. • Microbes do not try to cause disease. • Microbes are looking for food and defending themselves. Common strategies of pathogenicity A thorough understanding is esesntial to develop better, novel vaccin n es a d therapeutic agents for treatment and prevention How Microorganisms Enter a Host Learning Objectives Identify the principal portals of entry. Define ID50 and LD50 Using p,p examples, explain how microbes adhere to host cells