21. 3 There are Mechanism of facto many types of DNA Jun Fos p65-p50 dimer binding domains NF↓B 八AAA AP-1 may b regulated by Phosphorylation of ↓m ↓ Figure 28.19 Oncogenes - kB releases NF-k日 that code for transcription factors have mutations that Inactivate transcription Function of oncogenic factor (v-erbA and possibly v-o V-Rel has lost regions needed to stay in cytoplasm rel) or that activate transcription(v-jun and vvv wvoy V-IOS v-Rel may prevent p65/p50 fom v-Jun and v-Fos may activate target v-ErbA cannot activate orming dimer andor activating genes without responding to usual transcription, and also inhibits transcription 消当Figure 28.19 Oncogenes that code for transcription factors have mutations that inactivate transcription (v-erbA and possibly v￾rel) or that activate transcription (v-jun and v-fos). 21.3 There are many types of DNA￾binding domains