Clostridium tetani-Tetanospasmin disseminates systemically binds to ganglioside receptors inhibitory neurones in CNS glycIne o neurotransmitter stops nerve impulse to muscles spastic paralysis痉挛性麻痹 severe muscle contractions and Spasms can be fatalClostridium tetani -Tetanospasmin ◼ disseminates systemically ◼ binds to ganglioside receptors • inhibitory neurones in CNS ◼ glycine • neurotransmitter ◼ stops nerve impulse to muscles ◼ spastic paralysis痉挛性麻痹 ◼ severe muscle contractions and spasms ◼ can be fatal