2)respiratory regulation alteration of ventilation alteration of breathe out of co2 Paco2 t, central [HIt peripheral respiration t PaO2↓J( receptor) Paco2 tt (80mmHg) inhibition of respiratory center 3)cellular action exchanges of Ht and K2) respiratory regulation alteration of ventilation alteration of breathe out of CO2 PaCO2 central [H+ ] peripheral respiration PaO2 (receptor) PaCO2 (＞80mmHg) inhibition of respiratory center 3) cellular action exchanges of H+ and K+