Transcription is very similar to DNA replication but there are some important differencesi 1, RNA is made of ribonucleotides 2. RNa polymerase catalyzes the reaction 3. The synthesized rNA does not remain base-paired to the template DNA strand 4. Less accurate (error rate: 10-4)6 Transcription is very similar to DNA replication but there are some important differences: 1.RNA is made of ribonucleotides 2.RNA polymerase catalyzes the reaction 3.The synthesized RNA does not remain base-paired to the template DNA strand 4.Less accurate (error rate: 10-4)