Intermolecular and intramolecular Intermolecular: When two separate molecules react, the condensation is termed intermolecular a simple exam ple is the condensation of two amino acids to form the peptide bond characteristic of proteins. This reaction example is the opposite of hydrolysis, which splits a chem ical entity into two parts through the action of the polar water molecule, which itself splits into hydroxide and hydrogen ions If the union is between atoms or groups of the same molecule the reaction is termed intramolecular condensation and in many cases leads to ring formation An example is the Dieckmann condensation, in which the two ester groups of a single diester molecule react with each other to lose a small alcohol molecule and form a B ketoester product.Intermolecular and intramolecular • Intermolecular：When two separate molecules react, the condensation is termed intermolecular. – A simple example is the condensation of two amino acids to form the peptide bond characteristic of proteins. This reaction example is the opposite of hydrolysis, which splits a chemical entity into two parts through the action of the polar water molecule, which itself splits into hydroxide and hydrogen ions. • If the union is between atoms or groups of the same molecule, the reaction is termed intramolecular condensation, and in many cases leads to ring formation. – An example is the Dieckmann condensation, in which the two ester groups of a single diester molecule react with each other to lose a small alcohol molecule and form a β- ketoester product