Name ection: Question 3, continued ii)What is the genotype of the following individuals? Individual 1 Individual 2 Individual 3 iii)Suppose individual 5s parents have another child. What are the chances that this child will be affected? iv) This pedigree represents a disorder that is both lethal and relatively common in the population. Explain how this is possible? c)Consider the pedigree below showing the inheritance of two X-linked diseases, hemophilia A (factor VIll deficiency) and hemophilia b( factor IX deficiency). Factor VIll and factor IX are encoded by two different genes, located at different positions on the X chromosome. Note that no individual shown in this pedigree is affected with both hemophilia A and hemophila B henotypically norm =affected with hemophilia A =affected with hemophilia B 5 i)Write the genotypes for the following individuals at both the hemophilia a and hemophilia b disease loci. Clearly define your genotype symbols Individual Genotype 12345 ii) How do you account for individual 5 not being affected with either hemophilia A or hemophilia b? 7012Fall2003Name:___________________________________ Section:_____ 7.012 Fall 2003 6 Question 3, continued ii) What is the genotype of the following individuals? Individual 1 Individual 2 Individual 3 iii) Suppose individual 5’s parents have another child. What are the chances that this child will be affected? iv) This pedigree represents a disorder that is both lethal and relatively common in the population. Explain how this is possible? c) Consider the pedigree below showing the inheritance of two X-linked diseases, hemophilia A (factor VIII deficiency) and hemophilia B (factor IX deficiency). Factor VIII and factor IX are encoded by two different genes, located at different positions on the X chromosome. Note that no individual shown in this pedigree is affected with both hemophilia A and hemophila B. = affected with hemophilia B = phenotypically normal = affected with hemophilia A 1 2 3 4 5 i) Write the genotypes for the following individuals at both the hemophilia A and hemophilia B disease loci. Clearly define your genotype symbols. Individual Genotype 1 2 3 4 5 ii) How do you account for individual 5 not being affected with either hemophilia A or hemophilia B?