CCR-5 CXCR4 CD4 REGIONAL LYMPH NODES TCELL LANGERHANS CELLS MACROPHAGE Viremia and widespread seeding of lymphoid tissue - Anti-gp120 Ab HIV in acuoles Latent infection Low-level infection Latent infection Low-level infection Follicular dendritic cell Antigenic stimulation HIV reservoin Activation by cytokines Cytokine stimulation (TNF-( IL-6, GM-CSF) Extensive viral replication Extensive viral replication and CD4+ cell lysis (HIV reservoir) Severe CD4+ cell loss Transport to brain Opportunistic infections and neoplasms