LHON 12STRNA Wallace mutation Cyt b 16STRNA 11778GA ND6 NDS ND4: Arg 340 His NDI 16569bp Q 11778G→A ND 2 D4 ND 4L COXI D 3 COXII coxⅡ ATPase8 □ATPa8%6口 Complex1□tNAs □ Cytochrome b■ Complex4 IRNAWallace mutation 11778G→A 11778 G→A ND4: Arg 340 His LHON