Neonatal vulnerability Immature immune system skin/mucus membrane, low in Igg and complement, poor migration/phagocytosis, low in cytokine production y Unavoidable pathogen exposure during birth Peripartum stress Invasive procedures Exposure to highly resistant nosocomial organismsNeonatal Vulnerability ➢ Immature immune system • skin/mucus membrane, low in IgG and complement, poor migration/phagocytosis, low in cytokine production ➢ Unavoidable pathogen exposure during birth ➢ Peripartum stress ➢ Invasive procedures ➢ Exposure to highly resistant nosocomial organisms