HEMOGLOBINURIA RBC abnormality o Defects of rbc membrane structure and function (hereditary spherocytosis) e Deficiency of enzymes(favism) o Hemoglobinopathy(thalassemia) ●PNH Mechanical factor(artificial heart valve), infection or mismatched blood transfusionHEMOGLOBINURIA RBC abnormality ⚫ Defects of RBC membrane structure and function (hereditary spherocytosis) ⚫ Deficiency of enzymes (favism) ⚫ Hemoglobinopathy (thalassemia) ⚫ PNH Mechanical factor (artificial heart valve), infection or mismatched blood transfusion