Clinical manifestations to appear symptoms after 3 months of birth fair hair, hypopigmentation in skin. eczema special odor(mouse-like) discharged from urine, sweat mental retardation nod-like seizure or infantile spasmClinical manifestations • to appear symptoms after 3 months of birth • fair hair, hypopigmentation in skin, eczema • special odor (mouse-like) discharged from urine,sweat • mental retardation • nod-like seizure or infantile spasm