4. Meta bolism of ketone bodies aConcept: Acetone, acetoacetate and D-B-hydroxybutyrate are formed in liver 肝脏内脂肪酸氧化大量生成乙酰CoA,但不能彻底氧化,生成 酮体是必然的结果。在正常情况下,酮体可迅速渗透到其它组织 口 Product: acetyl CoA>acetoacetyl COA→β-羟-β-甲基戊二酰CoA(HMG CoA裂解)→ acetoacetate >(reduction) >D-B-hydroxybutyrate >( decarboxylation)>acetone4. Metabolism of ketone bodies ❑Concept: Acetone, acetoacetate and D--hydroxybutyrate are formed in liver. 肝脏内脂肪酸氧化大量生成乙酰CoA，但不能彻底氧化，生成 酮体是必然的结果。在正常情况下，酮体可迅速渗透到其它组织。 ❑Product: acetyl CoA→acetoacetyl CoA→ -羟- -甲基戊二酰CoA→ (HMG￾CoA裂解)→ acetoacetate → (reduction)→D--hydroxybutyrate →(decarboxylation)→acetone