Medical Genetics mtDNA Point Multiple deletions Several types of mutations Aging mtdna defect Cardiomyopath Myositis Deafness Inclusion body Diabetes Leber's optic COX- muscle External ne uro pa thy fibers ophthalmo plegia Leigh's MNGIE (PEO syndrome PEO Sporadic MELAS Wolfram Maternal MERRF Dominant NARP/MILS Depletion of R ecessive mtDNA Leigh's Single deletion Infantile Myopathy or duplication myopathy fatal Rhabdomyolysis Ataxia, FLater-onset' Sensory Leukodystrophy AZT treatment neuropathy Intense SDH staining Dia betes: Systemic disorders of a muscle fiber with Maternal mitochondrial inheritance Kearns-Sayre proliferation Pearson's PEO: SporadicMedical Genetics Intense SDH staining of a muscle fiber with mitochondrial proliferation mtDNA Point mutations Cardiomyopath y Leber's optic neuropathy Leigh's syndrome MELAS MERRF NARP/MILS Single deletion or duplication Ataxia, Leukodystrophy Diabetes: Maternal inheritance Kearns-Sayre Pearson's PEO: Sporadic Multiple deletions Aging Myositis Inclusion body COX- muscle fibers MNGIE PEO Wolfram Depletion of mtDNA Infantile myopathy Fatal "Later-onset" AZT treatment Several types of mtDNA defect Deafness Diabetes External ophthalmoplegia (PEO) Sporadic Maternal Dominant Recessive Leigh's Myopathy Rhabdomyolysis Sensory neuropathy Systemic disorders