Selectins and other caMs participate in leukocyte extravasation 1. Free leukocyte Selectin ligand 2. Transient rolling (specific leukocyte carbohydrate) .B2 integrin 3. Leukocyte activation PAF receptor rolling and firm adhesion ICAM-1 Endothelial (PAF activates integrin) activation Endothelial cell 1, P-selectin PAF synthesis Leukocyte adhesion (integrin bonds to 4. Extravasation ICAM-1)Selectins and other CAMs participate in leukocyte extravasation