perfect adaptation for small L K/k ef128 safe zone perfect adaptation for large L K/ eff18 0 6 8 10 K. L fine-tune: net phoshorylation rate and keff and keff2 so that a falls in safe zonesafe zone net phosphorylated rate perfect adaptation for large L perfect adaptation for small L 9 fine-tune: net phoshorylation rate and keff1 and keff2 so that α falls in safe zone