Reactions of Amines Electrophilic Aromatic Substitution of Arylamines Amino substituents are strongly activating,ortho-and para- directing groups in electrophilic aromatic substitution Often give polysubstituted products Aryl amines do not undergo Friedel-Crafts reactions due to the acid- base reaction between the nonbonding electrons of the amino group and the AIClg catalyst NH2 NH2 Br B 3Br2 H20 Br Aniline 2,4,6-Tribromoaniline (100%)Electrophilic Aromatic Substitution of Arylamines ▪ Amino substituents are strongly activating, ortho- and para￾directing groups in electrophilic aromatic substitution ▪ Often give polysubstituted products ▪ Aryl amines do not undergo Friedel-Crafts reactions due to the acid￾base reaction between the nonbonding electrons of the amino group and the AlCl3 catalyst Reactions of Amines