Histopathology of Uc Chronic changes Distorted crypt architecture of colon Transformed, disorganized, and loss of gland Loss of cupped cells Loss and disappearance of haustration, so much as straitness Thicking of the smooth muscle Malignant tumorHistopathology of UC Chronic changes: -Distorted crypt architecture of colon Transformed, disorganized, and loss of gland -Loss of cupped cells -Loss and disappearance of haustrations, so much as straitness -Thicking of the smooth muscle -Malignant tumor