Lincomycin Clindamycin Pharmacokinetics about 9o% protein-bound excretion via the liver bile, and urine penetrate well into most tissue, including bone, but not CSF.Pharmacokinetics • about 90% protein-bound • excretion via the liver,bile, and urine • penetrate well into most tissue, including bone, but not CSF. Lincomycin & Clindamycin