TABLE Reports of Particle Migration Year Author Prosthesis(n) Type of Particles Location(s) Animal studies 1973 Walker4 THr*(NA)** Polyethylene(Pe) lymph nodes(LN), alveolar walls 1974 Mendes 13THR(3) PE LN Human Autopsy Studies 1990Bos3 THR (32) PE Metal Regional and para-aortic LN Polymethylmethacrylate Human Operative studie 1974 Helm THR (2) Polyester Inguinal LN 1989 Gra THR (2) PE Metal Inguinal and paraaortic LN 1992 Langkamer THR(2) Metal Paraaortic LN and spleen 1993 Bauer TKR 1 PE. Carbon fiber Paraaortic LN 993 Shinto20 TKR(1) Metal LN 1993 O'Connell TSR (1) PE Axillary Ln THR, total hip replacement; TKR, total knee replacement; TSR, total shoulder replacement ** n, the number of animals, was not specifiedTABLE 1 Reports of Particle Migration Year Author Prosthesis (n) Animal Studies 1973 Walker24 THR* (NA)** 1974 Mendes13 THR (3) Human Autopsy Studies 1990 Bos3 THR (32) Human Operative Studie 1974 1989 1992 1993 1993 1993 Heilmann8 Gray6 Langkamer12 Bauer2 Shinto20 O'Connell15 THR (2) THR (2) THR (2) TKR (1) TKR (1) TSR (1) Type of Particles Polyethylene (PE) PE PE, Metal, Polymethylmethacrylate Polyester PE, Metal Metal PE,Carbon fiber Metal PE Location(s) lymph nodes (LN), alveolar walls LN Regional and para-aortic LN Inguinal LN Inguinal and paraaortic LN Paraaortic LN and spleen Paraaortic LN LN Axillary LN * THR, total hip replacement; TKR, total knee replacement; TSR, total shoulder replacement ** n, the number of animals, was not specified