Cliniacl manifestations General manifestations: irritability, temporary teeth eruption delayed, anterior fontanel closure delayed Muscles lack of tone Head: craniotabes, Ping-Pong ball, caput quadratum Chest: beading of the ribs pigeon breast deformity, Harrison groove Limb: Thickening of the wrists and ankles Bow-legs, knock-knees➢ General manifestations: irritability, temporary teeth eruption delayed，anterior fontanel closure delayed ➢ Muscles lack of tone ➢ Head: craniotabes, Ping-Pong ball,caput quadratum ➢ Chest: beading of the ribs, pigeon breast deformity, Harrison groove ➢ Limb: Thickening of the wrists and ankles Bow-legs, knock-knees Cliniacl manifestations