6. Many trinucleotides were found to promote the binding of specific aminoacyl-tRNA to ribosomes It was discovered in 1964 that a specific aminoacyl- trna would bind to the isolated ribosomes when the corresponding synthetic polynucleotide messenger or only the trinucleotide is present many genetic codes were revealed by examining which aminoacyl-tRNa is bound to the ribosomes mixed with specific trinucleotides using filter binding assay6. Many trinucleotides were found to promote the binding of specific aminoacyl-tRNA to ribosomes • It was discovered in 1964 that a specific aminoacyl￾tRNA would bind to the isolated ribosomes when the corresponding synthetic polynucleotide messenger or only the trinucleotide is present. • Many genetic codes were revealed by examining which aminoacyl-tRNA is bound to the ribosomes mixed with specific trinucleotides using filter￾binding assay