Norepinephrine and Epinephrine Metabolism 9o-t-9- Mo MHPG(3-甲氧4羟苯乙二醇): was used as CH3 an index of cns ne turnover Norepinephrine DOPGAL Epinephrine but generated mostly from aldehyde aldehyde reductase dehydrogenase COMT raphe MMA香草扁桃酸) sometimes used as an index of ne turnover Normetanephrine DOPEG DOMA Metanephrine Sulfate conjugates COMT COMT also prevalent CH,o OH H Elimination by kidneys MOPEG or MHPG VMA Urine MIPG-SO aldehyde reductase NMN-SO MN-SO CHao MAO MAO Relative amounts excreted MOPGALNorepinephrine and Epinephrine Metabolism MHPG (3-甲氧4-羟苯乙二醇): was used as an index of CNS NE turnover but generated mostly from periphery VMA(香草扁桃酸): sometimes used as an index of NE turnover Sulfate conjugates also prevalent or MHPG 6