7.03 Lecture 28-30 11/17/03,11/19/03,11/21/03 AKR HAS A GENE THAT SUPPRESSES TUMORS TUMORS NON-TUMORS c57 black× AKR AAbb aaBB AaBb All normal ! 13/16 normal::3/16 tumors A-B- aaB- aaB- aabb It looks like we've been lucky.Allele A at SSR37 appears to segregate with HD.But can you be confident that the HD gene is in close proximity to the SSR37 locus,or even that it is on chromosome 4? 107.03 Lecture 28-30 11/17/03, 11/19/03, 11/21/03 10 All normal . C57black X AKR 13/16 normal:: 3/16 tumors TUMORS NON-TUMORS AAbb aaBB AaBb A-B￾aaB￾aabb aaB￾AKR HAS A GENE THAT SUPPRESSES TUMORS It looks like we've been lucky. Allele A at SSR37 appears to segregate with HD. But can you be confident that the HD gene is in close proximity to the SSR37 locus, or even that it is on chromosome 4?