Eschweiler-Clarke reaction a,. The reductive methylation of primary or secondary amines employing formaldehyde and formic acid HCO 2H(excess RNH,+ Ch,o RN(CH3)2Organic Chemistry Organic Chemistry Xiamen Xiamen University University Eschweiler-Clarke Reaction Eschweiler-Clarke Reaction „ The reductive methylation of primary or secondary amines employing formaldehyde and formic acid: RNH 2 + CH 2 O HCO 2H( e x c e s s ) RN( C H 3 ) 2