安徽医科大学国际教育学院教案与讲稿 Teaching Plan for International Students,AHMU Title of the course:Drug therapy in neonates and pediatric patients Chapter:23 Teacher's name: Chang Yan Grade:2013 Department:Clinical Medicine,School of International Education Time:14:30-16:50 Date(D/M/Y):3/30/2016 Lecture Notes: 【List example】 2min Chloramphenicol therapy in newborns---Gray baby syndrom Why chloramphenicol causes gray baby syndrome? Chloramphenicol is metabolized by the liver.A baby's liver is not mature enough to metabolize this drug.Therefore the levels of Chloramphenicol increase in the baby's body,as there is no way for the baby to get rid of the drug.This causes cardiovascular collapse (severe hypotension),cyanosis, flaccidity,and vomiting. 【Pharmacokinetics】 20 min Drug absorption Absorption from I.M.injection sites Absorption from GIT Absorption from the rectum Drug distribution Total body water content Fat content Protein binding Drug Metabolism Generally slower drug metabolism in infants and neonates,mainly because activity of drug-metabolizing enzymes is lower than in adults Drug excretion GFR lower in neonates and children Tubular secretion rate is about 25-50%lower in newborn reaching adult levels at age 1-3 years 2安徽医科大学国际教育学院教案与讲稿 2 Teaching Plan for International Students, AHMU Title of the course: Drug therapy in neonates and pediatric patients Chapter: 23 Teacher’s name: Chang Yan Grade: 2013 Department: Clinical Medicine, School of International Education Time: 14:30—16:50 Date (D/M/Y): 3/30/2016 Lecture Notes: 【List example】 2 min Chloramphenicol therapy in newborns---Gray baby syndrom Why chloramphenicol causes gray baby syndrome? Chloramphenicol is metabolized by the liver. A baby's liver is not mature enough to metabolize this drug. Therefore the levels of Chloramphenicol increase in the baby's body, as there is no way for the baby to get rid of the drug. This causes cardiovascular collapse (severe hypotension), cyanosis, flaccidity, and vomiting. 【Pharmacokinetics】 20 min Drug absorption Absorption from I.M. injection sites Absorption from GIT Absorption from the rectum Drug distribution Total body water content Fat content Protein binding Drug Metabolism Generally slower drug metabolism in infants and neonates, mainly because activity of drug-metabolizing enzymes is lower than in adults Drug excretion GFR lower in neonates and children Tubular secretion rate is about 25-50% lower in newborn reaching adult levels at age 1- 3 years