Pathogenesis 、 Pharmacokinetics: 1 Pharmacokinetics of the bzd Most bzd are extensively metabolized by the liver. Some are metabolized to products which are active and may have a much longer half life than the parent drug The major route of metabolism is n-demethylation in the elderly Cimetidine↓一、Pharmacokinetics ： 1、Pharmacokinetics of the BZD • Most BZD are extensively metabolized by the liver. • Some are metabolized to products which are active and may have a much longer half life than the parent drug. • The major route of metabolism is N-demethylation. in the elderly Cimetidine Pathogenesis