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(B) Intermembrane space Cytc ytc ℃ Fe-SUOHzJUC Fe-S Center P) e UO+(+ nter Figure 14.22 LUOH (A)Diagram illustrating proposed structure and membrane topography of mitochondrial Complex Ill (ubiquinone: cytochrome-c oxidore- ductase, also known as cytochrome bG,).The complex is a dimer, with each monomer con taining multiple subunits, Ubiquinol (UQH-) is oxidized at Center P, while ubiquinone (UQ) is reduced at Center N. The two electrons from UQH2 take divergent paths, one being trans- ferred to mobile cytochrome c via a Rieske iron-sulfur center and cytochrome cy, the other reaching Center N via two b-type cytochromes The inhibitory sites of antimycin and myxo- Complex Ill thiazol are at Centers N and P, respectively Matrix Figure 4-6-3 (500kDa) (B)Crystal structure of a dimeric mammalian cytochrome bc, complexFigure 4-6-3
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