国生一 国生 ©Nebulizer Nebulizer Ultrasonic system ·Ultrasonic system US wave is formed by a piezoelectric crystal -Therapeutic mist It is converted into high-frequency acoustic vibrations The vibrations disrupt the surface and create oscillation waves The oscillation waves will produce an aerosol cloud at the solution surface High-frequency source 图生一 国生 New types of nebulizer Respimat Soft MistTM Inhaler The secret of Respimat is the extremely fine nozzle Respimat Soft MistTM Inhaler system. When the medication solution is forced through it, two fine jets of liquid are produced. The two jets of liquid converge at an optimised angle The impact of these converging jets generate the soft mist. 国垫生 圈生一 Learning objectives Respimat Soft MistTM Inhaler Concept:MDI,DPI,nebulizer,propellant, cold filling,pressure filling ·The mist is extremely fine(5.8μn average) It moves slowly,which is the basis for high Mechanisms of particle deposition in respiratory tract lung deposition. No requirement for forceful inspiration. 1010 Shanghai Jiao Tong University Nebulizer • Ultrasonic system Shanghai Jiao Tong University Nebulizer • Ultrasonic system • US wave is formed by a piezoelectric crystal • It is converted into high-frequency acoustic vibrations • The vibrations disrupt the surface and create oscillation waves • The oscillation waves will produce an aerosol cloud at the solution surface Shanghai Jiao Tong University New types of nebulizer • Respimat Soft MistTM Inhaler Shanghai Jiao Tong University Respimat Soft MistTM Inhaler • The secret of Respimat is the extremely fine nozzle system. • When the medication solution is forced through it, two fine jets of liquid are produced. • The two jets of liquid converge at an optimised angle • The impact of these converging jets generate the soft mist. Shanghai Jiao Tong University Respimat Soft MistTM Inhaler • The mist is extremely fine (5.8 µm average). • It moves slowly, which is the basis for high lung deposition. • No requirement for forceful inspiration. Shanghai Jiao Tong University Learning objectives Concept: MDI, DPI, nebulizer, propellant, cold filling, pressure filling Mechanisms of particle deposition in respiratory tract