Antihypertensive agents that act on PNS 1.Beta blockers(B受体阻断剂) Mechanism of action:(1)Reduce cardiac output;(2)inhibit renin release, AT-lI and aldosterone production,and lower peripheral resistance;(3)may decrease adrenergic outflow from the CNS. Therapeutic use:Recommended as first-line antihypertensive agents. Combined use with diuretics are common.More effective in treating hyper- tension in white than in black patients,and in young patients than elderly (due to high occurrence of chronic lung and heart diseases in the elderly). Especially useful in treating hypertension with preexisting conditions such as previous myocardia infarction,angina pectoris,migraine headache. Propranolol普蓁洛尔：A prototypic B-blocker that antagonizes B,andB2AR.t inhibits renin production(due to B,-antagonistic activity)and can be used in patients with high renin level.It causes no prominent postural hypotension in mild to moderate hypertension patients.This class of drugs also include timolol. Nadolol纳多洛尔 ↑balf-life Metoprolol獎托涪尔 Pindolol引哚洛尔 B2 antagonistic effeet BI antagonistic Partial 82 agonistic B1 and B2 antagonistic Propranolol普装洛尔 Acebutolol醋丁洛尔 Atenolol安替洛尔 Bl antagonistic Bl antagonistic Partial B2 agonistic half-life CH 1010 Antihypertensive agents that act on PNS 1. Beta blockers (β 受体阻断剂) Mechanism of action: (1) Reduce cardiac output; (2) inhibit renin release, AT-II and aldosterone production, and lower peripheral resistance; (3) may decrease adrenergic outflow from the CNS. Therapeutic use: Recommended as first-line antihypertensive agents. Combined use with diuretics are common. More effective in treating hyper￾tension in white than in black patients, and in young patients than elderly (due to high occurrence of chronic lung and heart diseases in the elderly). Especially useful in treating hypertension with preexisting conditions such as previous myocardia infarction, angina pectoris, migraine headache. Propranolol 普萘洛尔: A prototypic β-blocker that antagonizes β1 and β2 AR. It inhibits renin production (due to β1-antagonistic activity) and can be used in patients with high renin level. It causes no prominent postural hypotension in mild to moderate hypertension patients. This class of drugs also include timolol. O OH NH CH3 CH3 Propranolol 普萘洛尔 N H O OH NH CH3 CH3 Pindolol 吲哚洛尔 O OH NH CH3 CH3 NH O CH3 H3C Acebutolol 醋丁洛尔 O OH NH CH3 CH3 HO HO Nadolol 纳多洛尔 O OH NH CH3 CH3 O H3C Metoprolol 美托洛尔 O OH NH CH3 CH3 NH2 O Atenolol 安替洛尔 β1 antagonistic ↑ half-life β1 and β2 antagonistic ↑ half-life ↓ β2 antagonistic effect β1 antagonistic Partial β2 agonistic β1 antagonistic Partial β2 agonistic