Most fully blown cancers require inactivation of tumor suppressor genes and activation of oncogenes Inactivation of apc Take the case Tumor Suppressor genes of colon Activation of K-RAs ancer Oncogene Inactivation of p53 Tumor Suppressor gene Early Adenoma/ Normal Epithelium Dysplastic Crypt Late adenoma Carcinoma Metastasis U. UU KRAS TP53 Figure by MIT OCW 20-40 yearsMost fully blown cancers require inactivation of tumor suppressor genes and activation of oncogenes Inactivation of APC Tumor Suppressor genes Activation of K-RAS Oncogene Inactivation of p53 Tumor Suppressor gene 20 – 40 Years Take the case of Colon Cancer N orm al E pith eliu m E arly A d e n o m a / D ysplastic Cry pt L ate A d e n o m a C arcin o m a M etastasis A P C K R A S T P 5 3 Oth er C han g es Figure by MIT OCW