Example (old) 非典型安定药利培酮( Risperidone)中间体的合成 6,7, 8, 9-tetrahydro-3-(2-hydroxyethyl) 2-methyl pyrido[1, 2-a]pyrimidin-4-one O O HO NH2 Pd/C, EtOH12530℃HO入 9% Janssen: Risperdal(1993)Example （old） • 非典型安定药利培酮(Risperidone)中间体的合成 N N HO O N N HO O H2 , Pd/C, EtOH, 25-30℃ 69% 6,7,8,9-tetrahydro-3-(2-hydroxyethyl)- 2-methylpyrido[1,2-a]pyrimidin-4-one Janssen: Risperdal® (1993)