ORGANIC CHEMISTRY Chapter 15 2. Friedel-Crafts reactions usually give poor yields when powerful electron-withdrawing groups are present on the aromatic ring or when the ring bears an -NH. -NhR and -NR G NO 2-N(CH3)3-CO2H-C-R-CF3-SO3H-NHE eNH 2 Cl3Al-NHE Alcl Does not undergo a Friedel-Crafts reaction Department of Chemistry, Xiamen UniversityORGANIC CHEMISTRY Department of Chemistry, Xiamen University Chapter 15 2. Friedel-Crafts reactions usually give poor yields when powerful electron-withdrawing groups are present on the aromatic ring or when the ring bears an –NH2, –NHR, and –NR2 NO2 N(CH3)3 CO2H C R O CF3 SO3H NH2 G NH2 AlCl3 Cl3Al NH2 Does not undergo a Friedel-Crafts reaction