1 Local action a Rectal suppositories intended for localized action are most frequently used to relieve constipation or the pain, irritation, itching> and inflammation associated with hemorrhoids or other anorectal conditions A popular laxative, glycerin suppositories promote laxation by the localirritation of the mucous membranes1） Local action ◼ Rectal suppositories intended for localized action are most frequently used to relieve constipation or the pain, irritation, itching, and inflammation associated with hemorrhoids or other anorectal conditions. ◼ A popular laxative, glycerin suppositories promote laxation by the local irritation of the mucous membranes