Pathology e Type I DM: inflammation of pancreas e Type 2 DM: amyloidosis of pancreas e Large vessel: atherosclerosis Kidney diffuse or nodular glomerular 60 clerosis 目east 口 north Retina arteriolar sclerosis microaneurysm、 exudates、 new vessel seasonseason season S ormation Nerve: axon degeneration myelinolysisPathology ⚫ Type 1 DM：inflammation of pancreas ⚫ Type 2 DM：amyloidosis of pancreas ⚫ Large vessel ：atherosclerosis ⚫ Kidney ：diffuse or nodular glomerular sclerosis ⚫ Retina：arteriolar sclerosis、 microaneurysm、exudates、new vessel formation ⚫ Nerve：axon degeneration 、 myelinolysis 0 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 season 1 season 2 season 3 season 4 east west north