课程名称 Pharmacology IV 教材名称 Basic Clinical Pharmacology,14th edition 授课章节 Chapter2 Drug Receptors Pharmacodynamics 1. 敦学目标：含知识目标、技能（能力）目标 1. 知识目标： (1)To learn the typesand definition oftherapeuticaleffectsand adverse reactions. (2)To learn the definition and the significance ofdose-effect relationship. (3)To learn the basic concepts of receptor kinetics,the types of receptors,the second messengers,and the significance of receptor regulation. (4)To learn the definition of pharmacodynamics. (5)To understand the mechanisms of drugs'action. 2. 技能（能力）目标： 2. 授课内容（依据教学大细）及时间分配 I.The specificity and selectivity of drugs'action;pharmacologicaleffects,excitation and inhibition;therapeutic effectsofdrugs,etiological treatmentsand symptomatic treatme 2.Dose-effect relationship and dose-effect curve,efficacy,median lethaldose(LD50),potency,therapeutic index,margin of safety.[20 min] 3.The mechanisms of actionsof drugs.[10 min] 4.Receptor and drug:the definition and feature ofreceptor,significance of receptor on drug action,the definition of ligand,agonist,partialagonist,antagonist;the definition and课程名称 Pharmacology IV 教材名称 Basic & Clinical Pharmacology, 14th edition 授课章节 Chapter 2 Drug Receptors & Pharmacodynamics 1. 教学目标：含知识目标、技能（能力）目标 1. 知识目标： (1) To learn the types and definition of therapeutical effects and adverse reactions. (2) To learn the definition and the significance of dose-effect relationship. (3) To learn the basic concepts of receptor kinetics, the types of receptors, the second messengers, and the significance of receptor regulation. (4) To learn the definition of pharmacodynamics. (5) To understand the mechanisms of drugs’ action. 2. 技能（能力）目标： 2. 授课内容（依据教学大纲）及时间分配 1. The specificity and selectivity of drugs’ action; pharmacological effects, excitation and inhibition; therapeutic effects of drugs, etiological treatments and symptomatic treatments; adverse reactions, side reac tions, toxic effects, withdrawal effects and allergic reactions. [20 min] 2. Dose-effect relationship and dose-effect curve, efficacy, median lethal dose (LD50), potency, therapeutic index, margin of safety. [20 min] 3. The mechanisms of actions of drugs. [10 min] 4. Receptor and drug: the definition and feature of receptor, significance of receptor on drug action, the definition of ligand, agonist, partial agonist, antagonist; the definition and characteristics of competitive antagonist and non -competitive antagonist; affinity, intrinsic activity, the types of receptors, the definition and types of the second messenge rs, receptor desensitization. [15 min]