Unification of biometrics and mendelian genetics RA Fisher was a 20th century genius who made fundamental contributions to the fields of statistics and biology. In statistics, he developed analysis of variance(ANOVA), the maximum likelihood method for estimating the values of parameters based on experimental data, permutation testing to estimate statistical significance(P-values), and exact tests for estimating statistical significance in small samples In biology, Fisher(together with Sewall Wright and Sir Ronald A Fisher(1890-1962) J.B.S. Haldane) is considered one of the founders English statistician, evolutionary of the "Modern Evolutionary Synthesis, " which unified biologist, geneticist, eugenicist; Darwin s theory of natural selection with mendel- Published: The correlation Between relatives on the inspired concepts of modern genetics. Among many supposition of Mendelian contributions, Fisher was the first to propose the idea Inheritance”in1918 of heterozygote advantage to explain the persistence of harmful genetic variants in certain populationsUnification of biometrics and Mendelian genetics Sir Ronald A. Fisher (1890-1962) English statistician, evolutionary biologist, geneticist, eugenicist; Published: “The correlation Between relatives on the supposition of Mendelian Inheritance” in 1918. RA Fisher was a 20th century genius who made fundamental contributions to the fields of statistics and biology. In statistics, he developed analysis of variance (ANOVA), the maximum likelihood method for estimating the values of parameters based on experimental data, permutation testing to estimate statistical significance (P-values), and exact tests for estimating statistical significance in small samples. In biology, Fisher (together with Sewall Wright and J.B.S. Haldane) is considered one of the founders of the “Modern Evolutionary Synthesis,” which unified Darwin’s theory of natural selection with Mendel￾inspired concepts of modern genetics. Among many contributions, Fisher was the first to propose the idea of heterozygote advantage to explain the persistence of harmful genetic variants in certain populations