Medical Genetics Genetic-Clinical correlations Maternal inheritance Recurrence risks: Brother 30%o, Sister 8%o Nephew 46%/, Niece 10%, Male cousin 31, Female cousin 6%/ (G11778A) have negative family history 40 of patients with commonest mutation Large families with maternal inheritance: G11778& T14484C mutationsMedical Genetics Genetic-Clinical correlations: Maternal Inheritance • Recurrence risks: Brother 30%; Sister 8%; Nephew 46%; Niece 10%; Male cousin 31%; Female cousin 6% • 40% of patients with commonest mutation (G11778A) have negative family history • Large families with maternal inheritance: G11778 & T14484C mutations