Complement Deficiencies Congenital:Deficiencies of C7,C8,C9 “terminal complement components”. Markedly increased incidence of Neisserial infections. N.meningitidis:meningitis,bacteremia N.gonorrhoeae:STDs,bacteremia Acquired:consumption of complement proteins during extensive activation of the complement system. Complement Deficiencies Congenital: Deficiencies of C7, C8, C9 - “terminal complement components”. Markedly increased incidence of Neisserial infections. - N. meningitidis: meningitis, bacteremia - N. gonorrhoeae: STDs, bacteremia Acquired: consumption of complement proteins during extensive activation of the complement system