(1 Drug tolerance of narcotic analgesics dose with disease 2 Physical dependence: long time use suddenly reduce, withdrawal Psychological dependence(addiction obsessive-compulsive disorder 4 Pseudo-addiction: dose inadequate can be revised• ① Drug tolerance of narcotic analgesics: dose with disease. • ② Physical dependence: long time use, suddenly reduce, withdrawal. • ③ Psychological dependence (addiction): obsessive-compulsive disorder. • ④ Pseudo-addiction: dose inadequate, can be revised